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in clinical studies, as described below, januvia did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, warfarin, or oral contraceptives, providing in vivo evidence of a low propensity for causing drug interactions with substrates of cyp3a4, cyp2c8, cyp2c9, and organic cationic transporter oct .
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warfarin multiple daily doses of januvia did not meaningfully alter the pharmacokinetics, as assessed by measurement of s – or r warfarin enantiomers, or pharmacodynamics as assessed by measurement of prothrombin inr of a single dose of warfarin.
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it is unknown whether patients with a history of pancreatitis are at increased risk for the development of pancreatitis while using januvia.
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on the company s fourth-quarter 2012 earnings call, chief executive ken frazier told analysts that despite multiple competitors in the market, the januvia family retained over a 70 share of the global dpp-iv market.
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