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When compared with the control group, pretreatment with paroxetine was effective in preventing interferon-induced mood and cognitive symptoms, as well improving pain.
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The study included 38 patients paroxetine group, n 18; placebo group, n 20 ; there were equal numbers of men and women.
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paroxetine is also a nitric oxide synthase nos inhibitor, hence serum nitrite and nitrate levels are reduced in paroxetine users.